Pulmonary hypertension
Child: Neonate: 200 mcg/kg diluted with 0.5-1 ml of sodium chloride 0.9% for inj.
Intravenous
Pulmonary hypertension
Child: Neonate: Initially 1 mg/kg by IV inj over 2-5 min, followed by continuous IV infusion of 200 mcg/kg/hr (diluted with glucose 5% or sodium chloride 0.9%) if required. Monitor BP closely. Doses >300 mcg/kg/hr associated with cardiotoxicity and renal failure.
Oral
Peripheral vascular disease
Adult: 25-50 mg 4 times daily.
Parenteral
Peripheral vascular disease
Adult: Up to 50 mg by SC, IM, IV or slow intra-arterial inj.